Science & patent news

Design of a hyperstable 60-subunit protein icosahedron

The icosahedron is the largest of the Platonic solids, and icosahedral protein structures are widely used in biological systems for packaging and transport. There has been considerable interest in repurposing such structures for applications ranging from targeted delivery to multivalent immunogen presentation. The ability to design proteins that self-assemble into precisely specified, highly ordered icosahedral structures would open the door to a new generation...

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Design of a hyperstable 60-subunit protein icosahedron

The icosahedron is the largest of the Platonic solids, and icosahedral protein structures are widely used in biological systems for packaging and transport. There has been considerable interest in repurposing such structures for applications ranging from targeted delivery to multivalent immunogen presentation. The ability to design proteins that self-assemble into precisely specified, highly ordered icosahedral structures would open the door to a new generation...

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Proteome-wide covalent ligand discovery in native biological systems

Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes are considered ‘undruggable’. Fragment-based ligand discovery can identify small-molecule probes for proteins that have proven difficult to target using high-throughput screening of complex compound libraries. Although reversibly binding ligands are commonly pursued, covalent fragments provide an...

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The XPS 13 DE: Dell continues to build a reliable Linux lineage

Behold, the latest in Linux out-of-the-box: Dell's XPS 13 Developer's Edition (2016). (credit: Scott Gilbertson)

Hardware that ships with Linux installed isn't as rare as it used to be. System 76, Purism, ZaReason, and others have been cranking out hardware with Linux pre-installed for quite a while now. But while those of us who use...

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Lone wolf claims responsibility for DNC hack, dumps purported Trump smear file

In an intriguing follow-up to Tuesday's report that Russian hackers gained access to Democratic National Committee servers, an anonymous blogger has claimed he alone was responsible for the breach and backed up the claim by publishing what purport to be authentic DNC documents taken during the online heist.

In a blog post published Wednesday, someone with the handle Guccifer 2.0 published hundreds of pages of...

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