Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proved difficult to inhibit, and the effectiveness of agents that target key KRAS effectors has been thwarted by activation of compensatory or parallel pathways that limit their efficacy as single agents. Here we take a systematic approach towards identifying combination targets for trametinib, a MEK inhibitor approved by...
Tag Archives: strategy
The big problem with Twitter’s new curation strategy
Is curation the key to solving Twitter’s audience problem? As part of his return to Twitter, Jack Dorsey has capital to spend fixing the platform’s problems, but it won’t last long. First, the good news. Twitter is making...
Whitepages lays off 12 employees to adjust for new advertising strategy
Whitepages today confirmed with GeekWire that it laid off 12 employees as it shifts its advertising strategy. The Seattle-based company now employs “more than 180 employees,” according to Whitepages VP of Marketing and Communications Liz Powell, so about 6 percent of the staff was let go....