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USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites

USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes. Its effects on protein turnover are substrate-specific, for unknown reasons. We report that USP14 shows a marked preference for ubiquitin–cyclin B conjugates that carry more than one ubiquitin modification or chain. This specificity is conserved from yeast to humans and is independent of chain linkage type. USP14 has been...

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Bug in Magento puts millions of e-commerce sites at risk of takeover

Millions of online merchants are at risk of hijacking attacks made possible by a just-patched vulnerability in the Magento e-commerce platform.

The stored cross-site scripting (XSS) bug is present in virtually all versions of Magento Community Edition and Enterprise Edition prior to 1.9.2.3 and 1.14.2.3, respectively, according to researchers from Sucuri, the website security firm that discovered and privately reported the vulnerability. It allows attackers...

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