Two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in both animals and plants as organellar cation channels. Here we present the crystal structure of a vacuolar two-pore channel from Arabidopsis thaliana, AtTPC1, which functions as a homodimer. AtTPC1 activation requires both voltage and cytosolic Ca2+. Ca2+ binding to the cytosolic EF-hand domain triggers...
The global occurrence in water resources of organic micropollutants, such as pesticides and pharmaceuticals, has raised concerns about potential negative effects on aquatic ecosystems and human health. Activated carbons are the most widespread adsorbent materials used to remove organic pollutants from water but they have several deficiencies, including slow pollutant uptake (of the order of hours) and poor removal of many relatively hydrophilic micropollutants. Furthermore,...
The global occurrence in water resources of organic micropollutants, such as pesticides and pharmaceuticals, has raised concerns about potential negative effects on aquatic ecosystems and human health. Activated carbons are the most widespread adsorbent materials used to remove organic pollutants from water but they have several deficiencies, including slow pollutant uptake (of the order of hours) and poor removal of many relatively hydrophilic micropollutants. Furthermore,...
(credit: Uber)
SAN FRANCISCO—On Thursday, a federal judge admonished Uber over its questionable newly issued labor agreement. He also ruled that the new agreement does not affect members of the certified class of California drivers who are currently suing Uber over whether they should be considered employees.
Uber’s lawyer, Theodore Boutrous, said the company believed it was within...
The response of the Greenland Ice Sheet (GIS) to changes in temperature during the twentieth century remains contentious, largely owing to difficulties in estimating the spatial and temporal distribution of ice mass changes before 1992, when Greenland-wide observations first became available. The only previous estimates of change during the twentieth century are based on empirical modelling and energy balance modelling. Consequently, no observation-based estimates of...
An artist's illustration of the proposed Thirty Meter Telescope on Mauna Kea. (credit: Thirty Meter Telescope)
For astronomers seeking to build the world's largest telescope on Mauna Kea in Hawaii, it will be anything but a Mele Kalikimaka. Hawaiian media reported that heavy machinery parked near a construction site atop the mountain since March was removed...
