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From expert pitchfork user to competent Mac user

(credit: Kris Connor/ Getty Images)

I grew up in a low-tech household. My dad only replaced something if it caught fire. We owned about 15 cars (mostly Humber 80s), and 13 of them were used to keep the other two running. Same story for tractors and any other farm equipment you care to name. Dad’s basic...

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Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing

In 1943, Luria and Delbrück used a phage-resistance assay to establish spontaneous mutation as a driving force of microbial diversity. Mutation rates are still studied using such assays, but these can only be used to examine the small minority of mutations conferring survival in a particular condition. Newer approaches, such as long-term evolution followed by whole-genome sequencing, may be skewed by mutational ‘hot’ or...

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The first gravitational-wave source from the isolated evolution of two stars in the 40–100 solar mass range

The merger of two massive (about 30 solar masses) black holes has been detected in gravitational waves. This discovery validates recent predictions that massive binary black holes would constitute the first detection. Previous calculations, however, have not sampled the relevant binary-black-hole progenitors—massive, low-metallicity binary stars—with sufficient accuracy nor included sufficiently realistic physics to enable robust predictions to better than several orders of magnitude. Here...

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Intrinsic ferroelectric switching from first principles

The existence of domain walls, which separate regions of different polarization, can influence the dielectric, piezoelectric, pyroelectric and electronic properties of ferroelectric materials. In particular, domain-wall motion is crucial for polarization switching, which is characterized by the hysteresis loop that is a signature feature of ferroelectric materials. Experimentally, the observed dynamics of polarization switching and domain-wall motion are usually explained as the behaviour of...

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First experimental Zika vaccine gets nod from FDA, moves to human trials

(credit: CDC/ James Gathany)

The US Food and Drug Administration on Monday approved the first human trial of an experimental Zika vaccine, according to a joint announcement by the two companies behind the new therapy.

The companies, Inovio Pharmaceuticals, Inc., based in Pennsylvania, and GeneOne Life Science, Inc., based in South Korea, said that their DNA-based vaccine...

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