Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in immune complexes, and viral persistence. Although combinations of antiretroviral drugs usually suppress viral replication and reduce viral RNA to undetectable levels in blood, it is unclear whether treatment fully suppresses viral replication in lymphoid tissue reservoirs. Here we show...
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NFL: Microsoft Surface problems during AFC Championship ‘not caused by tablets’
The NFL wants to make it clear that Microsoft Surface tablets are not to blame for a technology malfunction during Sunday’s AFC Championship game. As GeekWire reported yesterday, the New England Patriots became “frustrated” during the second quarter of their 20-18 loss to Denver after the Surface tablets...
Tabletgate: Patriots say their Microsoft Surface devices stopped working during AFC Championship
Update: Here’s a statement from Microsoft: “Our team on the field has confirmed the issue was not related to the tablets themselves but rather an issue with the network. We worked with our partners who manage the network to ensure the issue was resolved quickly.”...
Facebook launches ‘Sports Stadium’ to give fans a place to chat during live games
Most sports fans and journalists that monitor online conversation during live sporting events probably utilize Twitter more than any other social media platform. Facebook wants that to change. The social media giant today unveiled the Facebook Sports Stadium, a new platform...
New York Knicks player shot, robbed during Uber ride
New York Knicks forward Cleanthony Early was shot in the leg after his Uber vehicle was pulled over by a group of masked robbers on Wednesday morning. The Wall Street Journal reported that Early left a nightclub in Queens and hopped into an Uber with his girlfriend. The vehicle was...
How to lead a global company: What Tableau’s CEO learned during his year in London
When Tableau Software CEO Christian Chabot told his board members that he wanted to work at the company’s satellite office in London for one year, most thought he was a little crazy. “I have never heard of anyone doing that,” one told...
Thermal vesiculation during volcanic eruptions
Terrestrial volcanic eruptions are the consequence of magmas ascending to the surface of the Earth. This ascent is driven by buoyancy forces, which are enhanced by bubble nucleation and growth (vesiculation) that reduce the density of magma. The development of vesicularity also greatly reduces the ‘strength’ of magma, a material parameter controlling fragmentation and thus the explosive potential of the liquid rock. The development of...
Drone falls from the sky, nearly striking World Cup skier during a race
A drone crashed to Earth during a World Cup slalom ski race in Italy today, nearly hitting skier Marcel Hirscher. The drone belonged to a TV broadcast crew and carried a heavy camera on it.
Hirscher, a four-time defending overall World Cup champion, appeared not to notice the drone crash that happened just over his right shoulder as he came down the slope. He came...
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection
Mycobacterium tuberculosis, a major global health threat, replicates in macrophages in part by inhibiting phagosome–lysosome fusion, until interferon-γ (IFNγ) activates the macrophage to traffic M. tuberculosis to the lysosome. How IFNγ elicits this effect is unknown, but many studies suggest a role for macroautophagy (herein termed autophagy), a process by which cytoplasmic contents are targeted for lysosomal degradation. The involvement of autophagy has been...
Polarized endosome dynamics by spindle asymmetry during asymmetric cell division
During asymmetric division, fate determinants at the cell cortex segregate unequally into the two daughter cells. It has recently been shown that Sara (Smad anchor for receptor activation) signalling endosomes in the cytoplasm also segregate asymmetrically during asymmetric division. Biased dispatch of Sara endosomes mediates asymmetric Notch/Delta signalling during the asymmetric division of sensory organ precursors in Drosophila. In flies, this has been generalized to...