Interruption of combination antiretroviral therapy (ART) in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open label clinical trial evaluating 3BNC117, a broad and potent neutralizing antibody (bNAb) against the CD4 binding site of HIV-1 Env1, in the setting of analytical treatment interruption (ATI) in 13 HIV-1-infected individuals. Participants with 3BNC117-sensitive virus outgrowth cultures were enrolled....
Tag Archives: during
The no-power lunch: Seattle food trucks used Square’s Offline Mode to make sales during outage
The power outage in downtown Seattle on Wednesday wasn’t going to keep office workers from eating, and thanks to one bit of technology from the payment service...
Regulation of black-hole accretion by a disk wind during a violent outburst of V404 Cygni
Accretion of matter onto black holes is universally associated with strong radiative feedback and powerful outflows. In particular, black-hole transients have outflows whose properties are strongly coupled to those of the accretion flow. This includes X-ray winds of ionized material, expelled from the accretion disk encircling the black hole, and collimated radio jets. Very recently, a distinct optical variability pattern has been reported in...
Regulation of black-hole accretion by a disk wind during a violent outburst of V404 Cygni
Accretion of matter onto black holes is universally associated with strong radiative feedback and powerful outflows. In particular, black-hole transients have outflows whose properties are strongly coupled to those of the accretion flow. This includes X-ray winds of ionized material, expelled from the accretion disk encircling the black hole, and collimated radio jets. Very recently, a distinct optical variability pattern has been reported in...
President Obama calls out Snapchat and LinkedIn during final White House correspondents’ dinner
Amid zingers directed at everyone from Donald Trump to himself, President Barack Obama briefly mentioned two tech giants during his final White House correspondents’ dinner Saturday evening.
The 40-minute monologue, which you can watch here, was certainly funny — well, maybe depending on your political views —...
Robust neuronal dynamics in premotor cortex during motor planning
Neural activity maintains representations that bridge past and future events, often over many seconds. Network models can produce persistent and ramping activity, but the positive feedback that is critical for these slow dynamics can cause sensitivity to perturbations. Here we use electrophysiology and optogenetic perturbations in the mouse premotor cortex to probe the robustness of persistent neural representations during motor planning. We show that...
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Cells receive growth and survival stimuli through their attachment to an extracellular matrix (ECM). Overcoming the addiction to ECM-induced signals is required for anchorage-independent growth, a property of most malignant cells. Detachment from ECM is associated with enhanced production of reactive oxygen species (ROS) owing to altered glucose metabolism. Here we identify an unconventional pathway that supports redox homeostasis and growth during adaptation to...
Astronaut Scott Kelly says he suffered damaging stress during year in space
During his year in space, NASA astronaut Scott Kelly said he could do another year if...
A hippocampal network for spatial coding during immobility and sleep
How does an animal know where it is when it stops moving? Hippocampal place cells fire at discrete locations as subjects traverse space, thereby providing an explicit neural code for current location during locomotion. In contrast, during awake immobility, the hippocampus is thought to be dominated by neural firing representing past and possible future experience. The question of whether and how the hippocampus constructs...
Sacramento Kings will host a startup pitch contest during an NBA game
Startup pitch contests happen all over the world at a variety of locations, but an NBA arena usually isn’t the first place you think of as a place where entrepreneurs tout their business ideas.
But the Sacramento Kings are breaking new...