Tag Archives: causes

T-Mobile customers can’t access new giveaway app after ‘high demand’ causes server slowdown

Many T-Mobile customers expecting their first freebies as part of the company’s new giveaway app were left disappointed Tuesday morning.

T-Mobile Tuesday, the wireless carrier’s new app revealed on Monday that offers weekly giveaways for food, movie tickets, game gear and other items, ran into what appeared to be server issues on Tuesday morning as customers tried accessing the app.

More Comments are closed
The Brazilian Zika virus strain causes birth defects in experimental models

Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. However, in 2007, vectored by Aedes aegypti mosquitoes, ZIKV caused the first noteworthy epidemic on the Yap...

More Comments are closed
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death. Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and is considered to be a metabolic predisposition to liver cancer. However, the role of adaptive immune responses in NAFLD-promoted HCC is largely unknown. Here we show, in mouse models and human samples, that dysregulation of lipid metabolism in...

More Comments are closed
Failure of RQC machinery causes protein aggregation and proteotoxic stress

Translation of messenger RNAs lacking a stop codon results in the addition of a carboxy-terminal poly-lysine tract to the nascent polypeptide, causing ribosome stalling. Non-stop proteins and other stalled nascent chains are recognized by the ribosome quality control (RQC) machinery and targeted for proteasomal degradation. Failure of this process leads to neurodegeneration by unknown mechanisms. Here we show that deletion of the E3 ubiquitin...

More Comments are closed
Safari Suggestions bug causes browser crashes in iOS and OS X

(credit: Andrew Cunningham)

A server-side problem with the Safari Suggestions feature in recent versions of iOS and OS X appears to be causing Safari to crash and hang for some users. Developer Steve Troughton-Smith helped to identify the issue overnight, though it has also been discussed in a pair of Reddit threads in the Apple subreddit. The problem...

More Comments are closed