Tag Archives: without

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction. Although most genetic diseases arise from point mutations, current approaches to point mutation correction are inefficient and typically induce an abundance of random insertions and deletions (indels) at the target locus resulting from the cellular response to dsDNA breaks. Here we report the development of ‘base...

More Comments are closed
Cell biology: Ubiquitination without E1 and E2 enzymes

A protein in the pathogenic bacterium Legionella pneumophila has been found to attach the modifying molecule ubiquitin to human proteins, using a mechanism that, surprisingly, does not involve cellular E1 and E2 enzymes.

Nature doi: 10.1038/nature17888

Nature Latest Research   STRATEGIES FOR A COMPANY’S INTELLECTUAL PROPERTY. IP protection is a part of your business strategy and...
More Comments are closed
Table for one: How to play board games without a group

(credit: Aurich / Getty Images)

Welcome to Ars Cardboard, our weekend look at tabletop games! Check out our complete board gaming coverage right here—and let us know what you think.

A common refrain we hear in the comments section of Ars Cardboard stories is, “Man, these games...

More Comments are closed