Interruption of combination antiretroviral therapy (ART) in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open label clinical trial evaluating 3BNC117, a broad and potent neutralizing antibody (bNAb) against the CD4 binding site of HIV-1 Env1, in the setting of analytical treatment interruption (ATI) in 13 HIV-1-infected individuals. Participants with 3BNC117-sensitive virus outgrowth cultures were enrolled....
Tag Archives: viral
Please read about the grandma whose Google search went viral. Thank you.
The internet is so taken aback by good manners that a tweet about a British grandma who used “please” and “thank you” as bookends to a Google search has achieved viral status.
We all have a family member who may be a little less...
Microbial oceanography: Viral strategies at sea
The finding that marine environments with high levels of host microbes have fewer viruses per host than when host abundance is low challenges a theory on the relative roles of lysogenic and lytic viral-survival strategies.
Nature doi: 10.1038/nature17303
Lytic to temperate switching of viral communities
Microbial viruses can control host abundances via density-dependent lytic predator–prey dynamics. Less clear is how temperate viruses, which coexist and replicate with their host, influence microbial communities. Here we show that virus-like particles are relatively less abundant at high host densities. This suggests suppressed lysis where established models predict lytic dynamics are favoured. Meta-analysis of published viral and microbial densities showed that this trend...
A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter
Cellular immunity against viral infection and tumour cells depends on antigen presentation by major histocompatibility complex class I (MHC I) molecules. Intracellular antigenic peptides are transported into the endoplasmic reticulum by the transporter associated with antigen processing (TAP) and then loaded onto the nascent MHC I molecules, which are exported to the cell surface and present peptides to the immune system. Cytotoxic T lymphocytes...
CDC issues travel advisory for 14 countries with alarming viral outbreaks
(credit: Sanofi Pasteur)
With mounting evidence that the mosquito-spread Zika virus is behind the skyrocketing numbers of severe birth defects in Brazil, the Centers for Disease Control and Prevention late Friday cautioned pregnant women and women planning to become pregnant to postpone travel to a set of Latin American and Caribbean countries and territories experiencing Zika...