Interruption of combination antiretroviral therapy (ART) in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open label clinical trial evaluating 3BNC117, a broad and potent neutralizing antibody (bNAb) against the CD4 binding site of HIV-1 Env1, in the setting of analytical treatment interruption (ATI) in 13 HIV-1-infected individuals. Participants with 3BNC117-sensitive virus outgrowth cultures were enrolled....
Tag Archives: treatment
Alpine Immune Sciences raises $48 million for cancer and autoimmune treatment
Seattle’s Alpine Immune Sciences says it has closed a $ 48 million Series A financing round, to fund the development of next-generation...
Risky stem cell treatment reverses MS in 70% of patients in small study
MS brain lesion as seen on an MRI. (credit: James Heilman, MD)
By obliterating the broken immune systems of patients with severe forms of multiple sclerosis, then sowing fresh, defect-free systems with transplanted stem cells, researchers can thwart the degenerative autoimmune disease—but it comes at a price.
In a small phase II trial of 24 MS patients,...
Freeze-dried poop pills being tested for obesity treatment
(credit: tacit requiem/Flickr)
‘The freeze-dried poop method’ might not sound like a weight-loss strategy that would catch on, but—as some researchers are now testing—it may be an effective way to slim down.
In a randomized, controlled clinical trial starting this year, researchers will test out such a fecal formula for the treatment of obesity. They’ll also try...
NASA’s newest women astronauts get the Glamour treatment: Want to join them?
That’s one small step for NASA’s women astronauts, one giant leap for Glamour magazine. Women have had a hard time getting their just deserts when it comes to human spaceflight: The “Mercury 13” were passed over in the early 1960s, and that was just...
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
In recent years, several associations between common chronic human disorders and altered gut microbiome composition and function have been reported. In most of these reports, treatment regimens were not controlled for and conclusions could thus be confounded by the effects of various drugs on the microbiota, which may obscure microbial causes, protective factors or diagnostically relevant signals. Our study addresses disease and drug signatures...