Three spacefliers from the International Space Station made a photogenic...
What a view! Space station trio sails home through picture-perfect clouds
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Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
The Flaviviridae are a family of viruses that cause severe human diseases. For example, dengue virus (DENV) is a rapidly emerging pathogen causing an estimated 100 million symptomatic infections annually worldwide. No approved antivirals are available to date and clinical trials with a tetravalent dengue vaccine showed disappointingly low protection rates. Hepatitis C virus (HCV) also remains a major medical problem, with 160 million...
‘Find the Founder in You’: An inspiring, animated journey through Seattle’s startup future
What will inspire you to change the world? That’s the underlying question in this special animated video, which tells the inspiring story of one startup founder’s journey, and envisions the future of the Seattle in the process.
This is the latest in a series of videos created by Killer Infographics, in partnership with GeekWire, for...
Dozens of companies breached through SAP bug patched years ago
More than 36 organizations—some in the gas, telecommunications, and steel manufacturing industries—have been breached by attackers exploiting a vulnerability in older SAP business applications that gives them remote access to highly confidential data, the US government-sponsored CERT warned Wednesday.
The attacks were carried out over the past three years by attackers exploiting the "invoker servlet," which is a...
Zero to 100 in two seconds! Hyperloop One zooms through first public speed test
The newly renamed Hyperloop One venture sent an electrically propelled sled down a Nevada test track at speeds that went...
Economy passengers may rage after being marched through first class
(credit: flickr user: Hideyuki KAMON)
Research on inequality usually looks at fairly static social structures like schools, transport, healthcare, or jobs. But sometimes glaring inequality can be quite fleeting, as researchers Katherine DeCelles and Michael Norton argue in a recent PNAS article. Their example? Coming face to face with just how awful airplane economy class is in...
Physics: Quantum problems solved through games
Humans are better than computers at performing certain tasks because of their intuition and superior visual processing. Video games are now being used to channel these abilities to solve problems in quantum physics. See Letter p.210
Nature 532 184 doi: 10.1038/532184a
Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis
Olefin metathesis has had a large impact on modern organic chemistry, but important shortcomings remain: for example, the lack of efficient processes that can be used to generate acyclic alkenyl halides. Halo-substituted ruthenium carbene complexes decompose rapidly or deliver low activity and/or minimal stereoselectivity, and our understanding of the corresponding high-oxidation-state systems is limited. Here we show that previously unknown halo-substituted molybdenum alkylidene species...
Virtual regality: Now you can crawl through King Richard III’s grave online in 3-D
One year after King Richard III’s remains were reburied, the much-maligned monarch’s skeleton has been exposed once again – this...
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms
Mutations disabling the TP53 tumour suppressor gene represent the most frequent events in human cancer and typically occur through a two-hit mechanism involving a missense mutation in one allele and a ‘loss of heterozygosity’ deletion encompassing the other. While TP53 missense mutations can also contribute gain-of-function activities that impact tumour progression, it remains unclear whether the deletion event, which frequently includes many genes, impacts...
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