Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide CRISPR/Cas9-based screen to identify host genes that, when edited, resulted in reduced flavivirus infection. Here, we validated nine human genes required for flavivirus infectivity, and these were associated with endoplasmic reticulum functions including translocation, protein degradation, and N-linked glycosylation. In particular, a subset of endoplasmic reticulum-associated...
Tag Archives: Screen
GeekWire Radio: Microsoft’s Satya Nadella looks ahead, a surprising study on screen time, and more
GeekWire Deals: Build great how-to videos with this screen recorder for Mac, now half-off
You thought when you moved away that your parents would stop asking to solve their tech problems. But they still call, text and email, asking you how to rotate a photo or backup their computer. And there’s only so much you can do via voice and...
Yahoo yanks Yahoo Screen hub, scatters “original” content across sites
Yahoo's push to host exclusive TV and video content appears to have hit a major speed bump, as the company confirmed it had closed its dedicated...