Genetic variation modulates protein expression through both transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, here we combine a multiplexed, mass spectrometry-based method for protein quantification with an emerging outbred mouse model containing extensive genetic variation from eight inbred founder strains. By measuring genome-wide transcript and protein expression in livers from 192 Diversity outbred mice, we identify...
Tag Archives: Scale
Materials science: Clockwork at the atomic scale
Design rules for exotic materials known as polar metals have been put into practice in thin films. The findings will motivate studies of how a phenomenon called screening can be manipulated to generate new phases in metals.
Nature doi: 10.1038/nature17890
Materials science: Clockwork at the atomic scale
Design rules for exotic materials known as polar metals have been put into practice in thin films. The findings will motivate studies of how a phenomenon called screening can be manipulated to generate new phases in metals.
Nature doi: 10.1038/nature17890
Quantum superposition at the half-metre scale
The quantum superposition principle allows massive particles to be delocalized over distant positions. Though quantum mechanics has proved adept at describing the microscopic world, quantum superposition runs counter to intuitive conceptions of reality and locality when extended to the macroscopic scale, as exemplified by the thought experiment of Schrödinger’s cat. Matter-wave interferometers, which split and recombine wave packets in order to observe interference, provide...
Quantum superposition at the half-metre scale
The quantum superposition principle allows massive particles to be delocalized over distant positions. Though quantum mechanics has proved adept at describing the microscopic world, quantum superposition runs counter to intuitive conceptions of reality and locality when extended to the macroscopic scale, as exemplified by the thought experiment of Schrödinger’s cat. Matter-wave interferometers, which split and recombine wave packets in order to observe interference, provide...
Scale dependence of rock friction at high work rate
Determination of the frictional properties of rocks is crucial for an understanding of earthquake mechanics, because most earthquakes are caused by frictional sliding along faults. Prior studies using rotary shear apparatus revealed a marked decrease in frictional strength, which can cause a large stress drop and strong shaking, with increasing slip rate and increasing work rate. (The mechanical work rate per unit area equals...