Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4CRBN E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour...
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H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex
After DNA replication, chromosomal processes including DNA repair and transcription take place in the context of sister chromatids. While cell cycle regulation can guide these processes globally, mechanisms to distinguish pre- and post-replicative states locally remain unknown. Here we reveal that new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL–MMS22L homologous recombination complex. We identify the TONSL...
Uber recruits safety experts to review company, make security recommendations
Uber’s new safety advisory board will meet for the first time next week, as a group of experts on everything from domestic violence to law enforcement will come together to give feedback to company executives. These kinds of third-party advisory groups are pretty common. This one was put together by Uber’s new chief security officer Joe Sullivan, who previously...