Myocardial infarction results in compromised myocardial function and heart failure owing to insufficient cardiomyocyte self-renewal. Unlike many vertebrates, mammalian hearts have only a transient neonatal renewal capacity. Reactivating primitive reparative ability in the mature mammalian heart requires knowledge of the mechanisms that promote early heart repair. By testing an established Hippo-deficient heart regeneration mouse model for factors that promote renewal, here we show that...
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The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression
Neoplastic pancreatic epithelial cells are believed to die through caspase 8-dependent apoptotic cell death, and chemotherapy is thought to promote tumour apoptosis. Conversely, cancer cells often disrupt apoptosis to survive. Another type of programmed cell death is necroptosis (programmed necrosis), but its role in pancreatic ductal adenocarcinoma (PDA) is unclear. There are many potential inducers of necroptosis in PDA, including ligation of tumour necrosis...
Amazon now has three CEOs: Tech powerhouse promotes Andy Jassy and Jeff Wilke to CEO roles of respective divisions
Amazon.com is changing the titles for the top bosses who run two of the company’s most lucrative business units.
The company today announced that longtime...
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death. Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and is considered to be a metabolic predisposition to liver cancer. However, the role of adaptive immune responses in NAFLD-promoted HCC is largely unknown. Here we show, in mouse models and human samples, that dysregulation of lipid metabolism in...
Tech Moves: Trulia promotes McLaughlin to chief economist; Smartsheet hires ex-Microsoft engineering leader
—Trulia promoted Ralph McLaughlin to the position of chief economist, leading its housing economics research team. In his new role, McLaughlin will provide Trulia customers with insights into the economy, housing trends and public policy as it relates to the real estate industry. Trulia, based in San Francisco, was purchased...
U.S. CTO Megan Smith promotes Obama tech initiatives with help from Seattle techies
U.S. Chief Technology Officer Megan Smith took to the stage last week at CES 2016 to highlight and encourage participation in a variety of technology initiatives being pursued by the White...
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
Colorectal cancer remains a major unmet medical need, prompting large-scale genomics efforts in the field to identify molecular drivers for which targeted therapies might be developed. We previously reported the identification of recurrent translocations in R-spondin genes present in a subset of colorectal tumours. Here we show that targeting RSPO3 in PTPRK-RSPO3-fusion-positive human tumour xenografts inhibits tumour growth and promotes differentiation. Notably, genes expressed...
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch and epidermal growth factor (EGF) signals supporting Lgr5+ crypt base columnar ISCs for normal epithelial maintenance. However, little is known about the regulation of the ISC compartment after tissue damage. Using ex vivo organoid cultures, here we show that innate lymphoid cells...