The mitochondrial matrix is unique in that it must integrate the folding and assembly of proteins derived from the nuclear and mitochondrial genomes. In Caenorhabditis elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, including mitochondrial chaperonins, to promote mitochondrial proteostasis. While misfolded mitochondrial-matrix-localized ornithine transcarbamylase induces chaperonin expression, our understanding of mammalian UPRmt...
Tag Archives: processing
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide CRISPR/Cas9-based screen to identify host genes that, when edited, resulted in reduced flavivirus infection. Here, we validated nine human genes required for flavivirus infectivity, and these were associated with endoplasmic reticulum functions including translocation, protein degradation, and N-linked glycosylation. In particular, a subset of endoplasmic reticulum-associated...
Impact of meat and Lower Palaeolithic food processing techniques on chewing in humans
The origins of the genus Homo are murky, but by H. erectus, bigger brains and bodies had evolved that, along with larger foraging ranges, would have increased the daily energetic requirements of hominins. Yet H. erectus differs from earlier hominins in having relatively smaller teeth, reduced chewing muscles, weaker maximum bite force capabilities, and a relatively smaller gut. This paradoxical combination of increased energy...
Common payment processing protocols found to be full of flaws
Credit card users could have their PINs stolen, and merchants could have their bank accounts pillaged, in a set of attacks demonstrated by researchers Karsten Nohl and Fabian Bräunlein at the Chaos Computing Club security conference.
Much research has been done into the chips found on credit cards and the readers and number pads used with these cards, but Nohl decided to take a different...
Processing and properties of magnesium containing a dense uniform dispersion of nanoparticles
Magnesium is a light metal, with a density two-thirds that of aluminium, is abundant on Earth and is biocompatible; it thus has the potential to improve energy efficiency and system performance in aerospace, automobile, defence, mobile electronics and biomedical applications. However, conventional synthesis and processing methods (alloying and thermomechanical processing) have reached certain limits in further improving the properties of magnesium and other metals....
Processing and properties of magnesium containing a dense uniform dispersion of nanoparticles
Magnesium is a light metal, with a density two-thirds that of aluminium, is abundant on Earth and is biocompatible; it thus has the potential to improve energy efficiency and system performance in aerospace, automobile, defence, mobile electronics and biomedical applications. However, conventional synthesis and processing methods (alloying and thermomechanical processing) have reached certain limits in further improving the properties of magnesium and other metals....
Two atoms make quantum memory, processing gate, and test of entanglement
(credit: University of Maryland)
Quantum systems are inherently fragile as any interactions with the outside world can change their state. That makes creating things like quantum memories rather challenging, since it can be hard to know if it actually preserves the information you put into it. To get around this, researchers have been looking into ways...
Ex-Buuteeq CEO Forest Key raises $6M for virtual reality video processing startup Pixvana
Another veteran team of Seattle-based entrepreneurs is starting a new business in the virtual reality industry. This time it’s Pixvana, a startup led by former Buuteeq CEO Forest Key that today announced a $ ...