Arrestins are cytosolic proteins that regulate G-protein-coupled receptor (GPCR) desensitization, internalization, trafficking and signalling. Arrestin recruitment uncouples GPCRs from heterotrimeric G proteins, and targets the proteins for internalization via clathrin-coated pits. Arrestins also function as ligand-regulated scaffolds that recruit multiple non-G-protein effectors into GPCR-based ‘signalsomes’. Although the dominant function(s) of arrestins vary between receptors, the mechanism whereby different GPCRs specify these divergent functions is...
Tag Archives: predicts
Virtual reality will make people more connected to humanity, not less, VR exec predicts
Virtual reality is the new tech craze, but some fear the future it offers. Opponents conjure up a bleak world where people will waste away in headsets living virtual lives because they prefer the virtual world to the real...
Updated NFL playoff picks: Microsoft Bing predicts Super Bowl champion
Bing Predicts updated its NFL playoff picks after Wild Card weekend, but still thinks the Patriots will win Super Bowl 50. Using models which involve “traditional statistical models coupled with social listening and search analysis,” Microsoft’s search engine laid out its NFL playoff picks...