Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4CRBN E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour...
Tag Archives: novel
Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation
Our intestinal microbiota harbours a diverse bacterial community required for our health, sustenance and wellbeing. Intestinal colonization begins at birth and climaxes with the acquisition of two dominant groups of strict anaerobic bacteria belonging to the Firmicutes and Bacteroidetes phyla. Culture-independent, genomic approaches have transformed our understanding of the role of the human microbiome in health and many diseases. However, owing to the prevailing...
Trash-sorting robots; cloud-based DJ simulators and more novel ideas from the 9Mile Labs startup accelerator
Eleven startups graduated from Seattle startup accelerator 9Mile Labs today after a 14-week program, each with a different vision for business-to-business software or cloud technology.
“It’s a very emotional time for all of us,” said...