After DNA replication, chromosomal processes including DNA repair and transcription take place in the context of sister chromatids. While cell cycle regulation can guide these processes globally, mechanisms to distinguish pre- and post-replicative states locally remain unknown. Here we reveal that new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL–MMS22L homologous recombination complex. We identify the TONSL...
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T. Rowe Price marks down investment in Apptio and other private tech companies, yet another sign of a cooling market
T. Rowe Price sunk gobs of money into companies such as Cloudera, Dropbox, Apptio and Evernote in recent years, oftentimes at lofty valuations. Now, the giant mutual fund manager is resetting some of those bets. According...
Technology Alliance names new CEO as tech trade group marks 20 years
Carol Rava has been named CEO of the Technology Alliance, the Seattle-based trade organization that advocates for the tech industry. She will replace Susannah Malarkey, who held the CEO role since the organization was formed in 1996 with assistance from Bill Gates Sr. “Today Washington...