Mutations disabling the TP53 tumour suppressor gene represent the most frequent events in human cancer and typically occur through a two-hit mechanism involving a missense mutation in one allele and a ‘loss of heterozygosity’ deletion encompassing the other. While TP53 missense mutations can also contribute gain-of-function activities that impact tumour progression, it remains unclear whether the deletion event, which frequently includes many genes, impacts...
Tag Archives: loss
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death. Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and is considered to be a metabolic predisposition to liver cancer. However, the role of adaptive immune responses in NAFLD-promoted HCC is largely unknown. Here we show, in mouse models and human samples, that dysregulation of lipid metabolism in...
Virgin Galactic set to unveil second SpaceShipTwo, 16 months after tragic loss of the first one
MOJAVE, Calif. – Virgin Galactic is rolling out a second SpaceShipTwo rocket plane for its public debut today, more than six years after the first SpaceShipTwo’s rollout...
30 years after the Challenger shuttle tragedy, the loss and legacies linger
It’s been 30 years since the loss of the shuttle Challenger and its crew on Jan. 28, 1986, but its impact is still being felt – sometimes with sadness, sometimes with hope for the future. Seven astronauts died when the Challenger broke apart 73...
Cisco gets a big patent win despite Supreme Court loss, overturns $64M verdict
Cisco Nexus switches. (credit: pchow98)
Cisco has finally quashed a long-running lawsuit brought by an Israeli patent-holding company called Commil USA. The case took a surprising number of detours, including a trip to the Supreme Court last year that looks almost unnecessary in hindsight.
In an opinion (PDF) published Monday, the US Court of Appeals for the Federal Circuit said...
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
Colorectal cancer remains a major unmet medical need, prompting large-scale genomics efforts in the field to identify molecular drivers for which targeted therapies might be developed. We previously reported the identification of recurrent translocations in R-spondin genes present in a subset of colorectal tumours. Here we show that targeting RSPO3 in PTPRK-RSPO3-fusion-positive human tumour xenografts inhibits tumour growth and promotes differentiation. Notably, genes expressed...
Spatial and temporal distribution of mass loss from the Greenland Ice Sheet since AD 1900
The response of the Greenland Ice Sheet (GIS) to changes in temperature during the twentieth century remains contentious, largely owing to difficulties in estimating the spatial and temporal distribution of ice mass changes before 1992, when Greenland-wide observations first became available. The only previous estimates of change during the twentieth century are based on empirical modelling and energy balance modelling. Consequently, no observation-based estimates of...
Climate science: A history of Greenland’s ice loss
Aerial photographs, remote-sensing observations and geological evidence together provide a reconstruction of mass loss from the Greenland Ice Sheet since 1900 — a great resource for climate scientists. See Letter p.396
Nature 528 341 doi: 10.1038/528341a