The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischaemia. Acute kidney injury (AKI) affects 3% of all hospitalized patients. Here we show that the mitochondrial biogenesis regulator, PGC1α, is a pivotal determinant of renal recovery from injury by regulating nicotinamide adenine dinucleotide (NAD) biosynthesis. Following renal ischaemia, Pgc1α−/− (also known as Ppargc1a−/−) mice...
Tag Archives: linking
Integrative modelling reveals mechanisms linking productivity and plant species richness
How ecosystem productivity and species richness are interrelated is one of the most debated subjects in the history of ecology. Decades of intensive study have yet to discern the actual mechanisms behind observed global patterns. Here, by integrating the predictions from multiple theories into a single model and using data from 1,126 grassland plots spanning five continents, we detect the clear signals of numerous...
Ford meets Amazon: Automaker to integrate Echo and Alexa with SYNC, linking cars to homes
Ford says it’s working to connect its SYNC in-car technology platform with Amazon’s Echo smart speaker and Alexa virtual assistant — letting drivers turn off the living-room lights from their car, for example, or start their vehicle using a voice command from the kitchen....