Fitness landscapes depict how genotypes manifest at the phenotypic level and form the basis of our understanding of many areas of biology, yet their properties remain elusive. Previous studies have analysed specific genes, often using their function as a proxy for fitness, experimentally assessing the effect on function of single mutations and their combinations in a...
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Landscape of somatic mutations in 560 breast cancer whole-genome sequences
We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was...
Multi-level marketing mobile service provider Solavei shuts down due to ‘competitive landscape’
Solavei is done. The Seattle-based startup, which used multi-level marketing tactics to win customers for its mobile phone service, announced that it will shut down the company on Dec. 4. In a webcast that aired on Thursday, Solavei CEO Ryan Wuerch explained that his company was not able to “reach...