Antibiotic-resistant bacterial infection is a serious threat to public health. Peptidoglycan biosynthesis is a well-established target for antibiotic development. MraY (phospho-MurNAc-pentapeptide translocase) catalyses the first and an essential membrane step of peptidoglycan biosynthesis. It is considered a very promising target for the development of new antibiotics, as many naturally occurring nucleoside inhibitors with antibacterial activity target this enzyme. However, antibiotics targeting MraY have not...
Tag Archives: insights
The Atlantic salmon genome provides insights into rediploidization
The whole-genome duplication 80 million years ago of the common ancestor of salmonids (salmonid-specific fourth vertebrate whole-genome duplication, Ss4R) provides unique opportunities to learn about the evolutionary fate of a duplicated vertebrate genome in 70 extant lineages. Here we present a high-quality genome assembly for Atlantic salmon (Salmo salar), and show that large genomic reorganizations, coinciding with bursts of transposon-mediated repeat expansions, were crucial...
Yes, billionaires do use LLCs: Legal insights on the new Chan-Zuckerberg charity
Priscilla Chan and Mark Zuckerberg’s decision to form an LLC, through which they’ll conduct charitable and philanthropic activities, made headlines earlier this week. The New York Times notes that other Silicon Valley billionaires have taken to using LLCs, and speculates that the Chan/Zuckerberg adoption of the vehicle may accelerate the trend, distinguishing a newer generation of...