Interruption of combination antiretroviral therapy (ART) in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open label clinical trial evaluating 3BNC117, a broad and potent neutralizing antibody (bNAb) against the CD4 binding site of HIV-1 Env1, in the setting of analytical treatment interruption (ATI) in 13 HIV-1-infected individuals. Participants with 3BNC117-sensitive virus outgrowth cultures were enrolled....
Tag Archives: humans
Scientists force computer to binge on TV shows and predict what humans will do
Low gravity and high radiation: Would humans remain human on Mars?
This early morning view of the inner wall of Gale Crater is ethereal. (credit: NASA)
People like Elon Musk and others in the "space settlement" camp believe NASA and the US space industry should colonize Mars and make homo sapiens a multi-planet species. Musk wants SpaceX to one day send colonists to Mars, while NASA is talking...
Post-invasion demography of prehistoric humans in South America
As the last habitable continent colonized by humans, the site of multiple domestication hotspots, and the location of the largest Pleistocene megafaunal extinction, South America is central to human prehistory. Yet remarkably little is known about human population dynamics during colonization, subsequent expansions, and domestication. Here we reconstruct the spatiotemporal patterns of...
Impact of meat and Lower Palaeolithic food processing techniques on chewing in humans
The origins of the genus Homo are murky, but by H. erectus, bigger brains and bodies had evolved that, along with larger foraging ranges, would have increased the daily energetic requirements of hominins. Yet H. erectus differs from earlier hominins in having relatively smaller teeth, reduced chewing muscles, weaker maximum bite force capabilities, and a relatively smaller gut. This paradoxical combination of increased energy...
Ancient gene flow from early modern humans into Eastern Neanderthals
It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000–65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a population that diverged early from other modern humans in Africa contributed genetically to...
IBM Watson AI XPRIZE offers $5M for projects that link humans and computers – but who’ll sign up?
The latest multimillion-dollar tech challenge – known as the IBM Watson AI XPRIZE – will be aimed at encouraging collaboration between humans and artificial intelligence software to solve the world’s big problems. But it’s not yet clear who will sign up for the $...
A group of mysterious humans left these tools in Indonesia over 118,000 years ago
A few of the hundreds of stone tools that researchers found at the Talepu excavation in Sulawesi, Indonesia. Camera lens cap is included for size comparison. (credit: Erick Setiabudi)
Over 118,000 years ago, on the island of Sulawesi in Indonesia, a group of humans settled down and made a home. The only evidence of their existence is a...
New videos prove crows can make complex tools that only humans have made before
Enlarge / New Caledonian crow uses a tool to grab insects deep inside a piece of wood.
Though we've long known that crows use tools to get food (and occasionally to amuse themselves), scientists have lacked definitive evidence. Which is why two intrepid researchers invented the crow tailcam, to record the inventiveness of these...
Pantone’s color factory is a superb example of how humans and computers can work in harmony
This Quartz video that goes inside Pantone‘s factory headquarters in Carlstadt, N.J., is simply amazing. Pantone’s color employees are required to have “near-perfect” color vision. These people can detect shades that most others cannot, and it’s incredible to watch them note differences...