An in-depth analysis of a close relative of animals, Capsaspora owczarzaki , provides clues to the changes in gene regulation that occurred during the transition to multicellularity.
Nature doi: 10.1038/nature18447
Tag Archives: gene
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
Genome-wide association studies (GWAS) have identified numerous genetic variants associated with complex diseases, but mechanistic insights are impeded by a lack of understanding of how specific risk variants functionally contribute to the underlying pathogenesis. It has been proposed that cis-acting effects of non-coding risk variants on gene expression are a major factor for phenotypic variation of complex traits and disease susceptibility. Recent genome-scale epigenetic...
BioViva’s Liz Parrish makes progress in controversial gene quest to reverse aging
The way BioViva founder Elizabeth Parrish sees it, biological aging is a disease – and she’s willing to bet her life on...
BioViva’s Liz Parrish makes progress in controversial gene quest to reverse aging
The way BioViva founder Elizabeth Parrish sees it, biological aging is a disease – and she’s willing to bet her life on...
Ancient gene flow from early modern humans into Eastern Neanderthals
It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000–65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a population that diverged early from other modern humans in Africa contributed genetically to...
Gene editing tech named Science magazine’s Breakthrough of the Year
3d render of a DNA spirals
CRISPR, a genome-editing technology that has been progressing rapidly in the last three years, has just been named Science’s Breakthrough of the Year. CRISPR is a futuristic technique that can be used to edit and manipulate the DNA of any organism—crops, livestock, and even humans. It can allow scientists...
In retrospect: Twenty-five years of thesex-determining gene
The discovery that the gene SRY on the mammalian Y chromosome drives testis development marked a turning point in the decades-long quest to understand the genetic underpinnings and evolution of sex determination.
Nature 528 343 doi: 10.1038/528343a