Inflammatory caspases cleave the gasdermin D (GSDMD) protein to trigger pyroptosis, a lytic form of cell death that is crucial for immune defences and diseases. GSDMD contains a functionally important gasdermin-N domain that is shared in the gasdermin family. The functional mechanism of action of gasdermin proteins is unknown. Here we show that the gasdermin-N domains of the gasdermin proteins GSDMD, GSDMA3 and GSDMA...
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Structural basis for activity regulation of MLL family methyltransferases
The mixed lineage leukaemia (MLL) family of proteins (including MLL1–MLL4, SET1A and SET1B) specifically methylate histone 3 Lys4, and have pivotal roles in the transcriptional regulation of genes involved in haematopoiesis and development. The methyltransferase activity of MLL1, by itself severely compromised, is stimulated by the three conserved factors WDR5, RBBP5 and ASH2L, which are shared by all MLL family complexes. However, the molecular...
Will the Samsung Family Hub Refrigerator transform your kitchen into a tech hub?
LAS VEGAS — Innovation in home appliances is always a big theme at CES, and this year’s show was no different. Samsung had one of the most notable products, introducing the Family Hub Refigerator with a...
Withings expands fitness family with button-sized, e-ink Go tracker
Withings is known for its elegant line of products as well as their typically high price tags. In an effort to appeal to the masses, the company debuted the baby of its fitness tracker family at CES 2016: the Withings Go. The coin-sized device promises to automatically track your activity and sleep, show your progress on its e-ink...
‘Amazon Mom’ becomes ‘Amazon Family’ in U.S. after long campaign by dad bloggers
Amazon has quietly changed the name of its “Amazon Mom” program to “Amazon Family” in the U.S., following a longstanding campaign by dad bloggers to get rid of a name that was increasingly out of touch with parental roles and in the 21st Century. The company is now...