Tag Archives: failure

Because failure is an option SpaceX can do stuff like land rockets on a boat

The Falcon 9 rocket sliced a dazzling arc through the early morning Florida sky on Friday. (credit: SpaceX)

NASA’s legendary flight director Gene Kranz entitled his memoir Failure is Not an Option, referring to his days in mission control from the Mercury missions through the Apollo program. That mindset helped Kranz and teams of engineers at...

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Failure of RQC machinery causes protein aggregation and proteotoxic stress

Translation of messenger RNAs lacking a stop codon results in the addition of a carboxy-terminal poly-lysine tract to the nascent polypeptide, causing ribosome stalling. Non-stop proteins and other stalled nascent chains are recognized by the ribosome quality control (RQC) machinery and targeted for proteasomal degradation. Failure of this process leads to neurodegeneration by unknown mechanisms. Here we show that deletion of the E3 ubiquitin...

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Harbingers of failure: meet the customers you don’t want to love your product

Unbeknownst to themselves, some of these apparently happy consumers are actually harbingers of failure. (credit: Flickr user Peter Hilton)

A central premise in marketing seems so obvious that it doesn’t even bear scrutiny: if customers give you positive feedback on your product, that’s good. And if those people buy the product repeatedly, that's even better.

But what...

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