Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-18 proteins. The NLRP3 inflammasome has been implicated in the pathogenesis of several acquired inflammatory diseases as well as cryopyrin-associated periodic...
Tag Archives: essential
An essential receptor for adeno-associated virus infection
Adeno-associated virus (AAV) vectors are currently the leading candidates for virus-based gene therapies because of their broad tissue tropism, non-pathogenic nature and low immunogenicity. They have been successfully used in clinical trials to treat hereditary diseases such as haemophilia B (ref. 2), and have been approved for treatment of lipoprotein lipase deficiency in Europe. Considerable efforts have been made to engineer AAV variants with...
Hating parts of Star Trek is an essential part of loving Star Trek
Enlarge / Star Trek Beyond might be good or it might be bad, but either way it belongs in the canon. (credit: Paramount Pictures)
Some other sci-fi movie is stealing most of the thunder this week, but Star Trek fans got some table scraps in the form of a trailer for Star Trek Beyond, the third film set...