Tag Archives: control

Three-dimensional control of the helical axis of a chiral nematic liquid crystal by light

Chiral nematic liquid crystals—otherwise referred to as cholesteric liquid crystals (CLCs)—are self-organized helical superstructures that find practical application in, for example, thermography, reflective displays, tuneable colour filters and mirrorless lasing. Dynamic, remote and three-dimensional control over the helical axis of CLCs is desirable, but challenging. For example, the orientation of the helical axis relative to the substrate can be changed from perpendicular to parallel...

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Magnetic mind control works in live animals, makes mice happy

(credit: Windell Oskay)

For a bunch of mind-controlled mice, walking into a magnetic field has never felt sooo good.

The imperceptible force that the genetically tweaked rodents wandered through fired up the reward-related circuits in their brains, likely conjuring the pure pleasure experienced when, for instance, they ate a yummy treat, researchers report Monday in Nature Neuroscience. Of...

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The peptidergic control circuit for sighing

Sighs are long, deep breaths expressing sadness, relief or exhaustion. Sighs also occur spontaneously every few minutes to reinflate alveoli, and sighing increases under hypoxia, stress, and certain psychiatric conditions. Here we use molecular, genetic, and pharmacologic approaches to identify a peptidergic sigh control circuit in murine brain. Small neural subpopulations in a key breathing control centre, the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG), express...

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Control of proteasomal proteolysis by mTOR
Motor neurons control locomotor circuit function retrogradely via gap junctions

Motor neurons are the final stage of neural processing for the execution of motor behaviours. Traditionally, motor neurons have been viewed as the ‘final common pathway’, serving as passive recipients merely conveying to the muscles the final motor program generated by upstream interneuron circuits. Here we reveal an unforeseen role of motor neurons in controlling the locomotor circuit function via gap junctions in zebrafish....

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Vascular biology: Transcriptional control of endothelial energy

The formation of blood vessels requires rapid proliferation of endothelial cells. The transcription factors FOXO1 and MYC have been found to regulate the metabolism and proliferation of vascular endothelial cells.

Nature doi: 10.1038/nature16866

Nature Latest Research   STRATEGIES FOR A COMPANY’S INTELLECTUAL PROPERTY. IP protection is a part of your business strategy and matches your commercial goals. A...
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SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

The carboxy-terminal domain (CTD) of the RNA polymerase II (RNAP II) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodelling. Here we show that a CTD arginine residue (R1810 in human) that is conserved across vertebrates is symmetrically dimethylated (me2s). This R1810me2s modification requires protein arginine methyltransferase 5 (PRMT5) and recruits the Tudor...

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