The Flaviviridae are a family of viruses that cause severe human diseases. For example, dengue virus (DENV) is a rapidly emerging pathogen causing an estimated 100 million symptomatic infections annually worldwide. No approved antivirals are available to date and clinical trials with a tetravalent dengue vaccine showed disappointingly low protection rates. Hepatitis C virus (HCV) also remains a major medical problem, with 160 million...
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Please read about the grandma whose Google search went viral. Thank you.
The internet is so taken aback by good manners that a tweet about a British grandma who used “please” and “thank you” as bookends to a Google search has achieved viral status.
We all have a family member who may be a little less...
Bird brains are dense—with neurons
What do you think they're using all those neurons for? (credit: Flickr user Teddy Llovet)
Birds are smart. They use tools, engage in social learning, plan for the future, and do a variety of other things that were once thought to be exclusively the stuff of primates. But hundreds of millions of years of evolution separate...
GeekWire Radio: The real reason Microsoft is buying LinkedIn for $26 billion
Access to LinkedIn’s trove of data about companies and professionals is a primary driver of Microsoft’s $ 26.2 billion acquisition of LinkedIn, says our guest...
Microsoft tests new tool to remove OEM crapware
Windows 10 already includes ways to clear out applications and data to repair misbehaving systems or prepare them to be sold, courtesy of the Refresh and Reset features added in Windows 8. Microsoft is now adding a third option: a new refresh tool.
Currently available only for Windows Insiders, the new tool fetches a copy of Windows online and performs a clean installation. The only...
Amazon venturing onto Powell’s home turf, picks Portland for third brick-and-mortar bookstore
For 45 years, Powell’s Books has defined what success means in the bookstore business.
Now, the highly-regarded Portland bookstore is getting some serious competition in its hometown from a company that...
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide CRISPR/Cas9-based screen to identify host genes that, when edited, resulted in reduced flavivirus infection. Here, we validated nine human genes required for flavivirus infectivity, and these were associated with endoplasmic reticulum functions including translocation, protein degradation, and N-linked glycosylation. In particular, a subset of endoplasmic reticulum-associated...
Whoa, Canada! Prime Minister Trudeau tries HoloLens at Microsoft’s new Vancouver office
Some politicians create their own reality, but today Justin Trudeau got to experience Microsoft’s augmented reality.
Canada’s Prime Minister tried out a Microsoft HoloLens holographic headset at...
AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
Autophagy is a highly conserved self-digestion process, which is essential for maintaining homeostasis and viability in response to nutrient starvation. Although the components of autophagy in the cytoplasm have been well studied, the molecular basis for the transcriptional and epigenetic regulation of autophagy is poorly understood. Here we identify co-activator-associated arginine methyltransferase 1 (CARM1) as a crucial component of autophagy in mammals. Notably, CARM1...
Latin American video giant Samba Tech opens Seattle office, launches new app
Samba Tech, a Latin American online video distributor, is opening a Seattle office and launched a new app this week.
The company is setting up shop in Seattle to be closer to Microsoft, a major partner, and to tap the region’s talent pool....