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NASA considers turning Curiosity rover into a scout for water on Mars mountain
Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumour cells and repress translation of specific messenger RNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its messenger RNA selectivity is proposed to reflect highly structured 5′ untranslated regions that depend strongly on eIF4A-mediated unwinding. However, rocaglate treatment may not phenocopy the loss of eIF4A...
Startup that turns stoves into charging stations wins University of Washington business plan competition
A startup that is looking to turn stoves into...
Twitter may let you add photos and links without cutting into your precious character count
In a move to get users to share more links and photos, Twitter may be dropping URLs from the character count, meaning they won’t cut into a tweet’s 140 character limit.
The change, leaked to Bloomberg but unconfirmed by Twitter as of yet, could show up...
Popcap brings Bejeweled into modern era with Bejeweled Stars
Match-3 games may be the perfect mobile entertainment apps. They’re easy to learn, can continually challenge you with ever-more-difficult puzzles and are just as fun whether you play for five minutes or for half an hour.
However, while some indie houses have come...
Bring an “escape room” into your living room… for $22
Welcome to Ars Cardboard, our weekend look at tabletop games! Check out our complete board gaming coverage right here—and let us know what you think.
Who knew being locked in a room would become so popular?
"Escape rooms" are so hot that even my sleepy Chicago...
Shares of Blucora soar after net income rises, continues push into financial services
Blucora, the Bellevue company formerly known as InfoSpace which is pushing heavily into financial services, posted strong results Thursday as a transformation continues under the direction of newly-appointed CEO and former Charles Schwab & Co. executive John S....
Amazon’s giant Seattle biospheres come into focus with installation of first glass panels
Workers are entering...
Structural insights into inhibition of lipid I production in bacterial cell wall synthesis
Antibiotic-resistant bacterial infection is a serious threat to public health. Peptidoglycan biosynthesis is a well-established target for antibiotic development. MraY (phospho-MurNAc-pentapeptide translocase) catalyses the first and an essential membrane step of peptidoglycan biosynthesis. It is considered a very promising target for the development of new antibiotics, as many naturally occurring nucleoside inhibitors with antibacterial activity target this enzyme. However, antibiotics targeting MraY have not...