Screwdriver. Pliers. Power drill. Get real. Homeowners know that the one tool you can’t live without is a hammer — MC Hammer?
If your walk-in closet doesn’t have enough baggy pants hanging in it, Trulia is apparently...
CBS and Paramount, the two studios that own the rights to Star Trek, announced a list of 10 guidelines for fan film creators this week. The studios are saying that they “will not object to, or take legal action against” filmmakers that follow the new rules (although the studios added that “CBS and Paramount Pictures reserve the right to revise, revoke and/or withdraw these...
Peter Clark is a...
OK,...
Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4CRBN E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour...
Just a couple of...
Directionally tuned signalling in starburst amacrine cell (SAC) dendrites lies at the heart of the circuit that detects the direction of moving stimuli in the mammalian retina. The relative contributions of intrinsic cellular properties and network connectivity to SAC direction selectivity remain unclear. Here we present a detailed connectomic reconstruction of SAC circuitry in mouse retina and describe two previously unknown features of synapse...
Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proved difficult to inhibit, and the effectiveness of agents that target key KRAS effectors has been thwarted by activation of compensatory or parallel pathways that limit their efficacy as single agents. Here we take a systematic approach towards identifying combination targets for trametinib, a MEK inhibitor approved by...
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