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.NET Core 1.0 released, now officially supported by Red Hat

Version 1.0 of .NET Core, the open source, cross-platform .NET runtime platform that was first announced in 2014, has been released today. .NET Core is arriving alongside ASP.NET Core 1.0, the open source, cross-platform version of Microsoft's Web development stack.

Microsoft picked an unusual venue to announce the release: the Red Hat Summit. One of the...

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HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

Interruption of combination antiretroviral therapy (ART) in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open label clinical trial evaluating 3BNC117, a broad and potent neutralizing antibody (bNAb) against the CD4 binding site of HIV-1 Env1, in the setting of analytical treatment interruption (ATI) in 13 HIV-1-infected individuals. Participants with 3BNC117-sensitive virus outgrowth cultures were enrolled....

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Unswayed by Axanar, CBS and Paramount offer 10 rules for fan film makers

CBS and Paramount, the two studios that own the rights to Star Trek, announced a list of 10 guidelines for fan film creators this week. The studios are saying that they “will not object to, or take legal action against” filmmakers that follow the new rules (although the studios added that “CBS and Paramount Pictures reserve the right to revise, revoke and/or withdraw these...

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A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4CRBN E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour...

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